On the splash page, there is an interaction combo box that you can change the presets. If you try to change it, the combo box selection doesn't change to what you selected.
The python uses this: USERPREF_MT_appconfigs
It looks like it is updating the data, because the interaction presets and key configuration are updated when you go into preferences > input.
I am on a Windows 7 machine, but I don't think it is OS specific. It does this on the official 2.69 release as well as the master branch in dev.
