When I start blender.exe I can the error "blender.exe has encountered a problem and needs to close". I have added this in bug 1707 as well but it remains closed.
A couple of versions ago I had this problem as well but it still started when I used the "-W Force opening without borders option". But that work-around has dissapeared as well.
Please view the information I added in bug 1707. If you need more information I'll happily supply it.
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Apparently this is caused by a dual monitor display. When I disable the second monitor Blender starts. Why didn't I find this out sooner?!
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This is a generic request to test your bug report and see if it is still an issue in 2.5alpha2 if so please let me know by making a comment in this report ie 'also in 2.5alpha2' and I will add it to the 2.5 bug list.