System Information
Mac OS X 10.10.4
NVIDIA GeForce 8600M GT 256 MB
Blender Version
Broken: 2.75a c27589e
In Blender Game Engine one situation where shape key drivers work is for bones that are parents and also deform a mesh.
The drivers fail when the armature is spawned during runtime.
Based on a attached .blend file with minimum amount of steps
Press P. Wait for second cube to spawn and watch. The first cube shape key drivers work. The second spawn cube is identical but the drivers don't work.