System Information
Operating system: Windows-10-10.0.18362 64 Bits
Graphics card: GeForce GTX 1080/PCIe/SSE2 NVIDIA Corporation 4.5.0 NVIDIA 436.30

Blender Version
Broken: version: 2.81 (sub 12), branch: master, commit date: 2019-09-28 23:19, hash: rB44d042094e21
Worked: 2.81 Alpha, 2019-09-19 20:35, hash: c8df6f2cf9df

Short description of error
In Object mode, using any of the transform tools with the "Affect Only Origins" checkbox unchecked does not transform the object. Instead, it transforms the origin point.
If "Affect Only Origins" is checked, then the transform tools will affect the mesh, but it does the opposite of what you are doing with the mouse.
For example, if you try to scale an object up with Affect Only Origins on, moving the mouse outwards will scale the mesh smaller, not larger as you would expect.

In Edit Mode, the transform tools work as they should.

Exact steps for others to reproduce the error
Open the blender default scene with the default cube.
In Object mode, select the cube.
Click on the Move tool (or press G)
Open the Options panel > Tool tab.
Turn off "Affect Only Origins" checkbox if it is already checked.
Move the mouse or the move gizmo.

WHAT SHOULD HAPPEN:
The cube should move.

INSTEAD: The origin point moves and the cube stays put.

Now, in the Options panel > Tool section, click on the "Affect Only Origins" checkbox to turn it on.
Move the cube with the Move tool or with the G shortcut key.

WHAT SHOULD HAPPEN:
Only the origin point should move.

INSTEAD:
The origin point will move, but the cube also moves in the opposite direction from where you are moving the mouse.