System Information
Operating system: Darwin-19.3.0-x86_64-i386-64bit 64 Bits
Graphics card: AMD Radeon R9 M390 OpenGL Engine ATI Technologies Inc. 4.1 ATI-3.5.5

Blender Version
Broken: version: 2.92.0, branch: master, commit date: 2021-02-24 16:25, hash: rB02948a2cab44
Worked: 2.91

My mouse settings have remained the same for many years, with new release my navigation is reversed.

In the settings, reversing any mouse setting has no effect, whether for zoom or scroll. Zero change in mouse behaviour.

"Invert zoom direction" with Mouse or Wheel - No effect
Fly and Walk- Invert mouse direction in "walk" - No effect

Exact steps for others to reproduce the error
Use a Mac Magic Mouse 2 with Blender, I suppose