I also uninstalled all instances, deleted corresponding directories to best my knowledge, used cleaner to remove invalid reg keys, and fresh installed 2.82; still nothing.

In T70313#868556, @Germano Cavalcante (mano-wii) wrote:

@Jonathan McIntyre (JMac), could you test with the latest daily build?
https://builder.blender.org/download/

(When testing remember to delete the startup file too)

I'm having this issue in 2.81a. If I delete the startup.blend file the issue goes away, but as soon as I save the startup file it starts back up. Is there a way to look at the contents of the startup.blend file in a editor or something. I also tried to look for instances of bpy.ops.wm.save_homefile() in the default blender directory but couldn't make sense of the related/surrounding code to help. Total noob here, just sharing what I came across.