I can confirm this issue.
As far as I can tell it happens when using 2 or more Graphics Cards while having more than one window open on blender and the windows are on Displays connected to 2 different GPUs and then you save the file and when you try to reload it, it crashes immediately.
When using a command console to load using the debug [-d] it show this error:
Win32 Error# (3221692624): <no system message>
Error: EXCEPTION_ACCESS_VIOLATION