**System Information**
windows 10 geforce 960
**Blender Version**
2.78 2016-09-26 12:42
**Short description of error**
Changes made to the layout aren't entirely remembered when I save the startup file and quit and start blender.
**Exact steps for others to reproduce the error**
Change the layout, save startup file, quit, start blender again. Especially try setting up a layout on two monitors with two blender windows; it completely forgot about the second window. I was going through all of the screen layouts in the Info Bar and changing them all so that the title/header bars are at the top of the panes, saving the startup file after each layout was changed, ending with changing the video layout. Then I went back to the default layout, saved the startup file again, quit, and started, and it starts in Video Editing instead of Default.